sixth James Bond novel, originally published on the 31 March 1958. This novel was inspired by Fleming's having read Sax Rohmer's Fu Manchu stories at Eton College.In Dr. No, M learns from the firm's neurologist that the poison was tetrodotoxin, which is obtained from the sex organs of the Japanese fish fugu. Tetrodotoxin paralyses the muscles of the victim while they stay fully conscious until eventually they die from asphyxiation. Bond is given first aid treatment by his friend Rene Mathis, while a doctor is urgently summoned (Klebb, we learn, is captured and has died). The Doctor had spent time in South America and had dealt with various poisons. He diagnoses curare poisoning and treats Bond accordingly. But his chances of survival are extremely slim.
Nonetheless, Bond survives. When he returns to duty, he is sent by M on a rest cure to Jamaica, a simple assignment to investigate the disappearance of Strangways, the head of Station J in Kingston, who had previously appeared in Live and Let Die. He learns that Strangways had been investigating the activities of Doctor Julius No, a reclusive Chinese-German who lives on an island called Crab Key that is said to be the home of a vicious dragon. Bond soon realizes that he is being watched. His hotel room is searched, a basket of poisoned fruit is delivered to his hotel room (supposedly a gift from the colonial governor), and then a deadly centipede is placed in his bed while he is sleeping.
With help of old friend Quarrel (who also previously appeared in Live and Let Die), as well as the beautiful Honeychile Rider, who visits the island to collect valuable shells (who, apart from her belt and diving knife is completely naked when Bond first sees her), Bond discovers that Doctor No, who operates a business harvesting and exporting guano, is also working with the Russians and has built an elaborate underground facility from which he can sabotage American missile tests. Dr. No was previously a member of a Chinese "tong" (criminal gang) and he was tortured and then had his hands cut off by order of the "tong" leaders after he stole a large amount of money from the "tong" treasury. The "tong" hit men then shot him in the chest, but No survived due to having dextrocardia (heart on the right side of the chest). No survived all this without revealing the location of the money he had stolen, and was left with artificial hands — and great wealth.
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